Metabolic breakdown of the REV-ERB activator SR9009 in camel liver and fungus for doping tests

SR9009, a synthetic REV-ERB agonist, is included on the World Anti-Doping Agency (WADA) Prohibited List for human sport.

• SR9009 has potential performance-enhancing properties.
• Concerns about its misuse extend to animal sports, particularly in equine and camel racing.
• The metabolic fate of SR9009 in racing camels is currently unclear.
• Investigating its biotransformation pathways is crucial for identifying biomarkers.
• Understanding these pathways is essential for developing effective anti-doping screening strategies for camel racing.

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