Using zebrafish with altered leiomodin 2b gene to model dilated heart disease

A mutation in Leiomodin 2 is associated with dilated cardiomyopathy in humans.

• Congenital heart disease is common in live births and requires effective diagnosis and treatment.
• A literature review identified gaps in understanding the gene networks involved in heart development.
• The gene lmod2b was selected for analysis based on its association with heart disease.
• In situ hybridization was used to study the expression of lmod2b during zebrafish embryonic development.
• CRISPR-Cas9 gene editing was performed to investigate potential cardiac abnormalities linked to lmod2b.

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