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Abstract
Prolonged exposure (10 weeks) to continuous light at night disrupts islet circadian clock function.
- Circadian disruption is correlated with type 2 diabetes mellitus and islet failure.
- Pancreatic islets have self-sustained circadian clocks that are crucial for β-cell health.
- Changes in the light-dark cycle can affect the timing of islet clock activity.
- Continuous light exposure impairs the amplitude, phase, and synchronization of islet clock activity.
- Diminished insulin secretion occurs with continuous light exposure due to reduced insulin pulse mass.
- These findings suggest mechanisms linking modern lifestyle factors to increased risk of islet failure in type 2 diabetes.
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