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Light exposure at night, sleep duration, melatonin, and breast cancer
Nighttime light exposure, sleep length, melatonin levels, and breast cancer risk: a dose-response analysis of observational studies
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Abstract
High artificial light at night exposure is associated with an increased risk for breast cancer (RR=1.17, 95% CI: 1.11-1.23).
- Ambient light at night exposure is not associated with breast cancer risk (RR=0.91, 95% CI: 0.78-1.07).
- An increase of 1 hour of sleep per night shows no significant association with breast cancer risk (RR=1.00, 95% CI: 0.995-1.01).
- An increase of 15 ng/mg creatinine in urinary 6-sulphatoxymelatonin is associated with a 14% reduced risk for breast cancer (RR=0.86, 95% CI: 0.78-0.95).
- No significant dose-response relationship between sleep duration and breast cancer was observed.
- The analysis indicated a linear dose-response trend for urinary 6-sulphatoxymelatonin levels (Ptrend=0.003).
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