Tracking how lipid nanoparticles carry mRNA vaccines in non-human primates

Lipid nanoparticles (LNPs) were observed distributing through muscle tissue and rapidly trafficking to draining lymph nodes after intramuscular injection.

• LNPs mimicking human vaccine delivery showed stochastic distribution to three different sets of draining lymph nodes.
• Histology confirmed LNP uptake in the draining lymph nodes.
• Antigen-presenting cells were identified as the primary immune cell type responsible for early LNP uptake and mRNA translation.
• The study provides insights into the biodistribution of mRNA vaccines at clinically relevant doses and injection sites.

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