How Lipid Nanoparticle Size and Stiffness Affect Their Movement Through the Space Between Cells

The model developed assesses how lipid nanoparticle size and bending rigidity influence transport through biological matrices.

• Lipid nanoparticles (LNPs) must penetrate various biological barriers to reach their target sites.
• The physicochemical properties of LNPs are critical for their ability to navigate complex environments like the brain.
• Deformation of LNPs in polymeric matrices affects their transport behavior.
• The study emphasizes the importance of the size ratio between particles and the surrounding matrix for effective transport.
• The model aids in understanding how size and rigidity of LNPs impact their diffusion through biological matrices.

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