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Lipid Nanoparticles Consisting of Sterol-Conjugated Ionizable Lipids Enable Prolonged and Safe mRNA Delivery
Sterol-linked ionizable lipid nanoparticles allow longer and safer mRNA delivery
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Abstract
Five ionizable lipids were selected for optimal LNP formulations at a 40-50% molar ratio.
- Luciferase mRNA-loaded lipid nanoparticles (LNPs) showed luminescence similar to commercial LNPs made with ALC-0315.
- These LNPs resulted in prolonged protein expression in mice.
- Accelerated stability studies indicated that the LNPs had good stability.
- LNPs carrying varicella-zoster virus (VZV) gE mRNA triggered both humoral and T-cell immune responses.
- Safety studies suggested that LNPs with these ionizable lipids had improved safety profiles compared to commercially available options.
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