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Lipopolysaccharide induces oxidative stress by triggering MAPK and Nrf2 signalling pathways in mammary glands of dairy cows fed a high-concentrate diet
Lipopolysaccharide may cause oxidative stress by activating stress and defense pathways in the milk-producing glands of dairy cows on a high-grain diet
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Abstract
A remarkable reduction in ruminal pH and an increase in lipopolysaccharide concentration were observed in cows fed a high-concentrate diet.
- High-concentrate feeding resulted in reduced milk yield compared to low-concentrate feeding.
- The mRNA levels of glutathione peroxidase and superoxide dismutase were down-regulated in cows on the high-concentrate diet.
- Increased mRNA intensity of oxidative stress-related genes, such as ERK, JNK, and p38, was noted in the high-concentrate group.
- Total antioxidant capacity was significantly decreased in the high-concentrate group, while malondialdehyde concentration increased.
- High levels of endogenous lipopolysaccharides may influence antioxidant responses related to specific cellular pathways.
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