Liver clock: Malalignment and entrainment therapeutics

The liver clock regulates the expression of 10%-15% of the transcriptome, impacting metabolism and health.

• The mammalian circadian system includes a central clock in the suprachiasmatic nucleus and peripheral clocks in organs like the liver.
• Clock genes and their protein products help regulate circadian rhythms in metabolism, physiology, and behavior.
• The central clock is primarily influenced by light-dark cycles, while liver clock genes can be affected by feeding cycles and nutrients.
• Disruptions in the central or liver clock may be associated with health issues, including increased cancer risk and metabolic disorders.
• Lifestyle measures such as time-restricted eating and light therapy have been explored for realigning circadian rhythms.

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