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Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice
Changes in Daily Clock Gene Activity with Day Length in Male Mice That Produce Melatonin
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Abstract
Fewer rhythmic genes were detected in mice subjected to long , with gene expression rhythms advanced by 4-6 hours.
- The central in mammals is influenced by seasonal daylength through retinal input to the suprachiasmatic nuclei (SCN).
- Long photoperiods significantly alter the timing and properties of the SCN clock and its driven rhythms.
- RNA sequencing revealed changes in expression for several clock-associated genes and genes related to light responses, neuropeptides, and neurotransmitters.
- Notable delays in gene expression were observed for a few specific genes, contrasting with the overall advancements in rhythmic gene expression timing.
- Transcriptional changes in certain genes may support neural network reconfiguration in the SCN during photoperiodic entrainment.
- The identified gene sets related to the SCN light response and neuropeptide signaling could provide insights into the molecular mechanisms of photoperiod plasticity.
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Key numbers
2488
Rhythmic Genes Detected
Out of 16,549 total transcripts analyzed.
1518
Differentially Expressed Genes
Between short and long .
4-6 h
Advanced Gene Expression Timing
In long compared to short.