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Somatostatin regulates central clock function and circadian responses to light
Somatostatin controls the brain's internal clock and daily responses to light
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Abstract
(SST) signaling in the is regulated by light and influences daily rhythms in behavior, showing differences between sexes.
- SST expression in the hypothalamus is modulated by changes in light exposure.
- Mice with altered SST signaling exhibit enhanced circadian responses to light and increased behavioral flexibility regarding photoperiod and environmental changes.
- Sex differences in photic responses are diminished in males, indicating that SST may interact with light-processing circuits differently based on sex.
- The number of neurons in the SCN that respond to light increases in the absence of SST signaling, suggesting a role in resetting the molecular clock.
- Lack of SST signaling affects the SCN's ability to encode changes in day length and influences synchronization among cells.
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Key numbers
25%
Increase in tdT+ cells
Observed after 12 weeks of exposure to long photoperiods.
30%
Increase in VIP-expressing neurons
Measured under L12 light conditions.
20%
Increase in GRP-expressing neurons
Also noted under L12 light conditions.