Vasopressin Resets the Central Circadian Clock in a Manner Influenced by Sex and Vasoactive Intestinal Polypeptide Signaling

V1A/B receptor agonists reset the phase of the SCN molecular clock in a time-dependent manner, with larger responses observed in female SCN.

• AVP signaling appears to influence the molecular rhythms in SCN neurons.
• Responses to V1A/B agonists are modulated by the sex of the SCN, suggesting a differential impact.
• Both Gαq and Gαs signaling pathways are involved in the SCN resetting induced by V1A/B agonists.
• The resetting response requires signaling from vasoactive intestinal polypeptide (VIP).
• This study underscores the importance of investigating clock function across both sexes.

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