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Somatostatin regulates the clock sensitivity to evening light
Somatostatin affects how the body clock responds to evening light.
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Abstract
Animals lacking (SST) show a significantly delayed phase of activity in long light conditions.
- Genetic deficiency in SST may disrupt normal responses to extended light exposure.
- Mice lacking the SSTR1 receptor also exhibit similar activity phase delays.
- SST appears to inhibit the activation of SSTR1 cells in response to light.
- Using an SSTR1 agonist, CH-275, may correct the phase delay in SST-deficient mice.
- These findings suggest a role for the SST-SSTR1 system in regulating the circadian clock's light sensitivity.
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Key numbers
4 h
Phase Delay
Mice lacking show a 4 h delay in activity onset under long photoperiod.
2×
SSTR1 Expression Increase
SSTR1 mRNA expression in of -deficient mice is approximately twice that of wild-type.