Local body clocks fall out of sync with the main internal clock in mice with inflammatory arthritis

Using the K/BxN mouse model, continuous monitoring of activity and gene expression is examined in relation to rheumatoid arthritis progression.

• Rheumatoid arthritis is characterized by fluctuations in inflammatory cytokine levels, leading to disease flares.
• Circadian proteins may play a role in regulating inflammatory responses in arthritis.
• Locomotor activity and circadian clock gene expression are monitored to assess their relationship with arthritis symptoms.
• The study explores the potential for these measurements to provide insights into the dynamics of therapeutic effects.

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