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Long-Term Efficacy and Safety of Nutritional and Pharmacological Strategies for Obesity
Long-Term Effects and Safety of Diet and Drug Treatments for Obesity
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Abstract
The Mediterranean diet (MedDiet) is associated with significant benefits for cardiovascular health and moderate long-term weight loss.
- The MedDiet shows moderate long-term weight loss but does not consistently outperform other diets.
- Very low-energy ketogenic therapy (VLEKT) is effective for rapid weight loss, though its long-term sustainability is uncertain.
- Pharmacological treatments like naltrexone/bupropion and liraglutide promote significant weight loss and improve metabolic markers.
- Challenges related to long-term adherence and potential side effects of these pharmacological options require further research.
- Both nutritional and pharmacological strategies are important tools for obesity management, with the need for more studies on their optimal duration and combinations.
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