Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5′‐monophosphate‐activated protein kinase pathway and reshaping gut microbiota

Lonicerae flos polysaccharides (LPs) exert protective effects against nonalcoholic fatty liver disease (NAFLD) in mice.

• LPs displayed sugar-chain aggregates and an amorphous structure, indicating stability under thermal stress at 150 °C.
• The treatment with LPs may prevent the progression of NAFLD induced by a high-fat and -cholesterol diet.
• LPs are associated with improvements in glucose metabolism, insulin resistance, lipid accumulation, inflammation, fibrosis, and autophagy.
• The protective effects of LPs against NAFLD may be mediated through the activation of the AMPK signaling pathway.
• LPs could reshape intestinal microbiota, with Desulfovibrio bacteria identified as playing a key role in this process.

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