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Tectorigenin ameliorated high-fat diet-induced nonalcoholic fatty liver disease through anti-inflammation and modulating gut microbiota in mice
Tectorigenin reduces fatty liver caused by high-fat diet in mice by lowering inflammation and changing gut bacteria
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Abstract
Tectorigenin (Tg) alleviated lipid profiles and liver steatosis in high-fat diet-fed mice.
- Tg reduced serum lipopolysaccharide (LPS) and total bile acid (TBA) levels.
- Inhibition of fat production and promotion of fat breakdown were observed in the liver.
- Tg restored the intestinal barrier and reduced the release of inflammation-causing substances.
- The growth of beneficial gut bacteria, such as Akkermansia, was promoted by Tg.
- Tg inhibited the growth of harmful gut microbes correlated with NAFLD symptoms.
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