LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain

Mar 25, 2024South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

LSD and psilocybin as treatments for long-lasting nerve-related pain: A summary of research on classic psychedelics for chronic pain

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Abstract

Classic psychedelic agents like lysergic acid diethylamide (LSD) and psilocybin may offer new approaches for managing chronic nociplastic pain.

  • Chronic nociplastic pain conditions often remain inadequately addressed by current management strategies.
  • Psychedelic agents have a long history of use in treating both chronic pain and mental health disorders.
  • Research into psychedelics for major depressive disorder may be relevant for understanding their potential role in chronic pain management.
  • The review provides a framework for healthcare providers to comprehend the mechanisms of action of psychedelics in pain pathways.

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