Psychedelics in the Treatment of Headache and Chronic Pain Disorders

May 13, 2022Current topics in behavioral neurosciences

Using Psychedelic Drugs to Treat Headaches and Long-Term Pain

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Abstract

Psychedelics have shown potential in managing headache and chronic pain disorders based on decades of anecdotal and early investigational reports.

  • Controlled studies of psilocybin and LSD are beginning to be conducted in headache and chronic pain management.
  • Psychedelics could provide lasting clinical effects after limited dosing, suggesting a new approach to disease management.
  • Further research is necessary to identify disease-specific treatments and understand the mechanisms behind the effects of psychedelics.
  • The review highlights neurobiological systems that may explain the unique clinical effects of psychedelics in headache and pain.

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