Response of cluster headache to psilocybin and LSD

Twenty-two of 26 psilocybin users reported that psilocybin aborted cluster headache attacks.

• 25 of 48 psilocybin users and 7 of 8 LSD users reported that their cluster headache periods were terminated.
• 18 of 19 psilocybin users and 4 of 5 LSD users experienced an extension of their remission periods.
• The findings suggest a potential therapeutic benefit of psilocybin and LSD for cluster headache patients.
• Further research on the effects of these substances on cluster headaches may be warranted.

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