What We Know and Don’t Know About LSD, Psilocybin, and Psilocin Effects in Rodents

Lysergic acid diethylamide (LSD), psilocybin, and psilocin are being evaluated as potential therapeutics for various psychiatric illnesses.

• Pre-clinical investigations in rodent models focus on the effects of these compounds on behavior and stress responses.
• Research has explored areas such as anxiety, depression-like behavior, and substance use.
• Three knowledge gaps have been identified for further research: sex differences, oral dosing, and chronic dosing regimens.
• A thorough understanding of the in vivo pharmacology of these compounds could enhance their clinical application.

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