Full text is available at the source.
Abstract
Lysosomal activation induces somatic histone H3.3 production that may transmit longevity in Caenorhabditis elegans.
- Lysosomes play a role beyond degradation, preparing offspring for stress.
- Histone H3.3 produced from lysosomal activation moves to the germline.
- Histone H3.3 is methylated at K79, which is associated with longevity.
- This work links metabolic processes, chromatin changes, and epigenetic inheritance.
Simplified