Effects of macronutrient manipulation on postprandial metabolic responses in overweight males with high fasting lipids during simulated shift work: A randomized crossover trial

Postprandial glucose and insulin responses were significantly higher after consumption of a meal high in sugar and saturated fat compared to a control meal.

• The test meal contained 16% total sugar and 26% saturated fat, while the control meal had 8% total sugar and 5% saturated fat.
• Incremental area under the curve (iAUC) for glucose was p = 0.04 and for insulin was p = 0.02, indicating significant differences.
• Postprandial triglyceride responses did not show a statistically significant difference between the two meals (p = 0.72).
• No changes in the expression of circadian genes clock and Per 1-3 were observed after either meal.

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