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Abstract
Excessive interferon signaling remodels macrophage peroxisomes, leading to impaired inflammation resolution and lung repair during severe respiratory viral infections.
- Loss of peroxisomes in macrophages is associated with impaired recovery from respiratory viral infections.
- Peroxisomes play a role in lipid metabolism and mitochondrial health specific to different types of macrophages.
- Peroxisomes enhance tissue repair and regeneration in the lungs following viral infections.
- Dysfunctional peroxisomes may contribute to increased activation of inflammasomes and release of IL-1β in macrophages.
- Enhancing peroxisome biogenesis pharmacologically could alleviate symptoms and consequences of COVID-19 in animal models.
- Macrophage peroxisome dysfunction is linked to chronic lung issues and fibrosis after SARS-CoV-2 infection.
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