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The Mammalian Circadian Time-Keeping System
The Body Clock System in Mammals
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Abstract
persist with a period of approximately 24 hours due to an internal autonomous clock.
- Circadian rhythms are driven by a cellular feedback loop involving the Period and Cryptochrome genes.
- The accumulation of specific proteins leads to oscillations in gene expression that regulate daily metabolic processes.
- The serves as a central pacemaker that coordinates numerous cellular clocks throughout the body.
- In isolated cultures, the suprachiasmatic nucleus maintains its rhythmic activity indefinitely.
- Solar time synchronization occurs through direct connections from specialized retinal photoreceptors to the suprachiasmatic nucleus.
- Circadian timing influences various biological functions, including autonomic, endocrine, and behavioral responses.
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