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The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior
The Internal Clock of VIP Receptor Cells Controls Timing and Consistency of Daily Behavior
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Abstract
Approximately 35% of suprachiasmatic nucleus (SCN) cells express the neuropeptide receptor VPAC2, which plays a critical role in circadian rhythm regulation.
- Deletion of the VPAC2 receptor in these cells lengthened the intrinsic circadian rhythm period.
- The lengthening of the circadian rhythm period was also observed in the behavioral rhythms of male mice.
- Variability in circadian periods increased in SCN slices from mice with VPAC2 cell deletion.
- Circadian behavioral rhythms were severely disrupted when VPAC2-expressing cells lost their circadian competence.
- VPAC2-expressing cells are a distinct subset within the SCN circuit, essential for maintaining circadian rhythm stability.
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Key numbers
24 h
Period Lengthening
Behavioral period of VPAC2-Cre mice with intact .
∼35%
Cell Deletion Impact
Proportion of SCN cells expressing VPAC2.