Aberrant Gating of Photic Input to the Suprachiasmatic Circadian Pacemaker of Mice Lacking the VPAC2Receptor

Apr 9, 2004The Journal of neuroscience : the official journal of the Society for Neuroscience

Abnormal light signal processing in the brain’s daily clock of mice missing the VPAC2 receptor

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Abstract

Circadian rhythms in SCN clock gene expression are abolished in mice lacking the VPAC(2) receptor.

  • The wild-type mouse SCN shows elevated levels of pERK and c-FOS during subjective day compared to subjective night.
  • No diurnal or circadian variation in pERK or c-FOS levels is observed in the SCN of Vipr2(-/-) mice.
  • In constant darkness, light pulses during subjective night increase pERK and c-FOS expression in wild-type mice but not in Vipr2(-/-) mice.
  • Light pulses during both subjective day and night increase pERK and c-FOS expression in Vipr2(-/-) mice.
  • Photic stimuli activate intracellular pathways in Vipr2(-/-) mice but do not engage core clock mechanisms.

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