Journal of biological rhythms

Exercise helps restore body rhythms in mice lacking certain brain chemical signals

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Scheduled voluntary exercise for 6 hours daily can promote improvements in circadian rhythms in genetically modified mice.

  • In constant dark, wild-type mice exhibit strong rhythmicity with a period of approximately 23.5 hours, while VIP(-/-) and Vipr2(-/-) mice show weak rhythms with periods of less than 23 hours.
  • VIP(-/-) and Vipr2(-/-) mice synchronize rapidly to scheduled voluntary exercise in less than 7 days, unlike wild-type mice, which take over 35 days.
  • After 21 to 50 days of scheduled voluntary exercise, most Vipr2(-/-) mice maintain near 24-hour behavioral rhythms, whereas very few VIP(-/-) mice achieve this.
  • Scheduled daily exercise may serve as a noninvasive intervention for improving circadian rhythms in conditions with disrupted timekeeping.

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