Role of vasoactive intestinal peptide in seasonal encoding by the suprachiasmatic nucleus clock

Apr 20, 2012The European journal of neuroscience

How a specific brain chemical helps the body’s internal clock track seasonal changes

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Abstract

Mice lacking vasoactive intestinal peptide (VIP) exhibit profound deficits in adapting their behavioral and physiological rhythms to changes in light conditions.

  • VIP is essential for the encoding of seasonal information in circadian rhythms.
  • Neural activity recordings showed that the circadian rhythms of VIP knockout mice were largely unaltered under light-dark conditions.
  • Significant differences between VIP knockout and normal mice emerged when placed in constant darkness, indicating altered rhythm compensation.
  • VIP knockout mice demonstrated no adaptation to variations in photoperiod, impacting their behavioral and physiological responses.

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