Brain research

Missing PAC1 receptor changes daily patterns of a key signaling molecule in the brain’s internal clock of mice

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The absence of PAC1 signaling affects circadian VIP mRNA expression in mice.

  • PACAP in the retinohypothalamic tract transmits light information to the suprachiasmatic nucleus through the PAC1 receptor.
  • Identical VIP mRNA rhythms were observed in both PAC1-/- and wild type mice during light/dark cycles.
  • Distinct differences in the oscillation pattern of VIP mRNA expression were noted between PAC1-/- and wild type mice in constant darkness.
  • The findings indicate that PAC1 signaling may influence circadian rhythms of VIP mRNA expression.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Related papers

Sep '04
Age-related changes in daily patterns of messenger RNA for a blood vessel regulator and its receptors in the brain's daily rhythm center of male rats
top 20% journal
cited by 45 papers
comparative study
May '04
Daily and internal clock patterns of brain signaling molecules in night-active and day-active rodents
cited by 120 papers
comparative study
Feb '10
How the brain chemicals PACAP and VIP help light control gene activity in the body's internal clock
cited by 42 papers
research support, n.i.h., extramural
Jul '07
Location and activity of two signaling proteins and their receptors in the mouse ovary
top 20% journal
cited by 32 papers
research support, non-u.s. gov't
Jun '04
Presence of VIP and PACAP receptor messages in peptide-producing cells of the rat's body clock and its output areas
top 20% journal
cited by 59 papers
research support, non-u.s. gov't
Nov '17
Roles of PAC1 and VPAC2 receptors in how light affects behavior and body functions in mice with one or both receptors altered
top 30% journal
cited by 32 papers
journal article
Mar '03
Peptide signals play a key role in controlling the body's daily rhythms in the brain's clock center
top 20% journal
cited by 59 papers
research support, non-u.s. gov't
Oct '08
Changes in light and non-light timing shifts in mice lacking 5-HT1A receptors
cited by 36 papers
research support, non-u.s. gov't
Sep '04
Timed calorie restriction changes production of key signaling molecules in the brain's biological clock
top 20% journal
cited by 14 papers
comparative study

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
yesterday7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
1 week ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
2 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
3 weeks ago7 studies
issue #40
Male mice lived 12% longer when they ate only during an 8-hour window at night
4 weeks ago7 studies
issue #38
Emergency doctors had 67% higher odds of chronic pain when working evening shifts vs. morning shifts
6 weeks ago7 studies
issue #36
Night owls show 77% higher risk of job burnout among firefighters
8 weeks ago7 studies
issue #35
Bacteria exposure resets your internal clock independently of immune responses
9 weeks ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
10 weeks ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
11 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief