Lack of the PAC1 receptor alters the circadian expression of VIP mRNA in the suprachiasmatic nucleus of mice

Jan 2, 2007Brain research

Missing PAC1 receptor changes daily patterns of a key signaling molecule in the brain’s internal clock of mice

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Abstract

The absence of PAC1 signaling affects circadian VIP mRNA expression in mice.

  • PACAP in the retinohypothalamic tract transmits light information to the suprachiasmatic nucleus through the PAC1 receptor.
  • Identical VIP mRNA rhythms were observed in both PAC1-/- and wild type mice during light/dark cycles.
  • Distinct differences in the oscillation pattern of VIP mRNA expression were noted between PAC1-/- and wild type mice in constant darkness.
  • The findings indicate that PAC1 signaling may influence circadian rhythms of VIP mRNA expression.

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