Journal of neurophysiology

Disrupted daily brain activity rhythms in the body clock area of mice lacking a key signaling molecule

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Updated

Abstract

Approximately 91% of SCN cells from normal mice exhibit rhythmic electrical activity.

  • Mice lacking functional VPAC(2) receptors show an inability to sustain behavioral rhythms and lack detectable electrical rhythms in the SCN.
  • Rhythmic cell proportions in SCN slices decrease from about 91% in normal mice to 62% in VIP-deficient mice.
  • Remaining rhythmic cells in VIP-deficient mice show decreased amplitude in their electrical activity.
  • VIP-deficient mice demonstrate variability in the period and timing of their SCN electrical rhythms, aligning with changes in their behavior.
  • Blocking VPAC(2) receptors in VIP-deficient slices significantly reduces the number of oscillating neurons, indicating ongoing receptor activity.

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