Disrupted Neuronal Activity Rhythms in the Suprachiasmatic Nuclei of Vasoactive Intestinal Polypeptide-Deficient Mice

Dec 8, 2006Journal of neurophysiology

Disrupted daily brain activity rhythms in the body clock area of mice lacking a key signaling molecule

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Approximately 91% of SCN cells from normal mice exhibit rhythmic electrical activity.

  • Mice lacking functional VPAC(2) receptors show an inability to sustain behavioral rhythms and lack detectable electrical rhythms in the SCN.
  • Rhythmic cell proportions in SCN slices decrease from about 91% in normal mice to 62% in VIP-deficient mice.
  • Remaining rhythmic cells in VIP-deficient mice show decreased amplitude in their electrical activity.
  • VIP-deficient mice demonstrate variability in the period and timing of their SCN electrical rhythms, aligning with changes in their behavior.
  • Blocking VPAC(2) receptors in VIP-deficient slices significantly reduces the number of oscillating neurons, indicating ongoing receptor activity.

AI simplified

Full Text

Full text is available at the source.
View full text ↗

Related papers

Mar '05
Vasoactive intestinal polypeptide helps control daily rhythms and coordination in mammal brain clock cells
cited by 684 papers
comparative study
Dec '05
Gastrin-releasing peptide supports daily cell rhythms in the brain's clock without VIP-VPAC2 signaling
top 5% journal
cited by 116 papers
research support, non-u.s. gov't
Feb '01
Vasoactive intestinal polypeptide shifts the timing of the rat's brain internal clock in a lab setting
top 20% journal
cited by 126 papers
research support, non-u.s. gov't
Jan '03
The mouse VPAC2 receptor supports daily cell rhythms and response to a signaling molecule in the brain’s internal clock
top 20% journal
cited by 125 papers
comparative study
Aug '18
Specialized Brain Cells Needed for Normal Light-Based Resetting of the Body’s Internal Clock
top 5% journal
cited by 146 papers
research support, n.i.h., extramural
Aug '02
Effects of a blood vessel–relaxing peptide on rat brain cells that control daily rhythms
top 20% journal
cited by 48 papers
research support, non-u.s. gov't
Oct '17
Development of Daily Biological Rhythms and Their Coordination in the Brain's Internal Clock
top 5% journal
cited by 90 papers
research support, non-u.s. gov't
May '11
Neuropeptide signals differently influence timing and rhythm control in the brain's main and other body clocks
top 30% journal
cited by 22 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #30
Your hair can reveal your circadian rhythm from a single sample
yesterday7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
1 week ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
2 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
3 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
4 weeks ago7 studies
issue #25
Your brain's master clock has 7 distinct neuron types with specific jobs
5 weeks ago7 studies
issue #24
Sleep disruption in teens linked to altered circadian gene expression and future heart disease risk
6 weeks ago7 studies
issue #23
Morning-loaded eating suppresses ghrelin more than evening meals — and artificial light disrupts immune rhythms in wild rodents
7 weeks ago7 studies
issue #22
Evening people have 83% higher depression risk, while gut bacteria shape your body clock
8 weeks ago7 studies
issue #21
Social jetlag linked to teen depression, while dairy-rich breakfasts improve blood sugar in diabetes
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief