Effects of Vasoactive Intestinal Polypeptide on Neurones of the Rat Suprachiasmatic Nuclei In Vitro

Aug 3, 2002Journal of neuroendocrinology

Effects of a blood vessel–relaxing peptide on rat brain cells that control daily rhythms

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Approximately 50% of rat SCN neurones respond to vasoactive intestinal polypeptide (VIP).

  • The primary response to VIP in SCN neurones is a suppression of spontaneous firing rate, while a minority of cells exhibit activation.
  • Responses to VIP are mimicked by the VPAC(2) receptor agonist Ro 25-1553 and blocked by the selective VPAC(2) receptor antagonist PG 99-465.
  • Activation of SCN cells occurs in response to the PAC(1) receptor agonist maxadilan, with 40% of cells responding.
  • Responses to VIP are not influenced by antagonists targeting ionotropic glutamate receptors.
  • The duration of VIP-induced suppression in firing rate is affected by the GABA(A) receptor antagonist bicuculline.

AI simplified

Full Text

Full text is available at the source.
View full text ↗View full text (PDF) ↗

Related papers

Feb '01
Vasoactive intestinal polypeptide shifts the timing of the rat's brain internal clock in a lab setting
top 20% journal
cited by 126 papers
research support, non-u.s. gov't
Jan '03
The mouse VPAC2 receptor supports daily cell rhythms and response to a signaling molecule in the brain’s internal clock
top 20% journal
cited by 125 papers
comparative study
Jun '04
Presence of VIP and PACAP receptor messages in peptide-producing cells of the rat's body clock and its output areas
top 20% journal
cited by 59 papers
research support, non-u.s. gov't
Aug '99
The main type of VIP receptor found in rat prostate membranes is VPAC1
top 20% journal
cited by 2 papers
research support, non-u.s. gov't
Dec '06
Disrupted daily brain activity rhythms in the body clock area of mice lacking a key signaling molecule
top 30% journal
cited by 97 papers
comparative study
Oct '04
VPAC2-R helps pituitary peptides trigger fat breakdown in rat fat cells
cited by 31 papers
research support, non-u.s. gov't
Mar '05
Vasoactive intestinal polypeptide helps control daily rhythms and coordination in mammal brain clock cells
cited by 684 papers
comparative study
Apr '97
Roles of VIP and PACAP receptors in controlling rat spinal neurons' responses to sensory signals
top 30% journal
cited by 77 papers
research support, non-u.s. gov't
Mar '03
Peptide signals play a key role in controlling the body's daily rhythms in the brain's clock center
top 20% journal
cited by 59 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #30
Your hair can reveal your circadian rhythm from a single sample
yesterday7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
1 week ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
2 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
3 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
4 weeks ago7 studies
issue #25
Your brain's master clock has 7 distinct neuron types with specific jobs
5 weeks ago7 studies
issue #24
Sleep disruption in teens linked to altered circadian gene expression and future heart disease risk
6 weeks ago7 studies
issue #23
Morning-loaded eating suppresses ghrelin more than evening meals — and artificial light disrupts immune rhythms in wild rodents
7 weeks ago7 studies
issue #22
Evening people have 83% higher depression risk, while gut bacteria shape your body clock
8 weeks ago7 studies
issue #21
Social jetlag linked to teen depression, while dairy-rich breakfasts improve blood sugar in diabetes
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief