Journal of neuroendocrinology

Effects of a blood vessel–relaxing peptide on rat brain cells that control daily rhythms

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Approximately 50% of rat SCN neurones respond to vasoactive intestinal polypeptide (VIP).

  • The primary response to VIP in SCN neurones is a suppression of spontaneous firing rate, while a minority of cells exhibit activation.
  • Responses to VIP are mimicked by the VPAC(2) receptor agonist Ro 25-1553 and blocked by the selective VPAC(2) receptor antagonist PG 99-465.
  • Activation of SCN cells occurs in response to the PAC(1) receptor agonist maxadilan, with 40% of cells responding.
  • Responses to VIP are not influenced by antagonists targeting ionotropic glutamate receptors.
  • The duration of VIP-induced suppression in firing rate is affected by the GABA(A) receptor antagonist bicuculline.

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