The Journal of neuroscience : the official journal of the Society for Neuroscience

Gastrin-releasing peptide supports daily cell rhythms in the brain's clock without VIP-VPAC2 signaling

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Abstract

In behaviorally rhythmic Vipr2(-/-) mice, the majority of detected SCN neurons displayed circadian firing patterns with estimated periods similar to the animals' behavior.

  • Transgenic mice lacking the VPAC2 receptor exhibit disrupted behavioral rhythms, with only a minority maintaining predictable activity cycles.
  • In behaviorally arrhythmic Vipr2(-/-) mice, only a small fraction of SCN neurons showed oscillatory activity.
  • Exogenous gastrin-releasing peptide (GRP) enhanced SCN cellular rhythms in slices from Vipr2(-/-) mice, indicating a potential modulatory effect.
  • Blockade of BB2 receptors suppressed neuronal oscillations, suggesting their involvement in rhythm generation.
  • In wild-type mice, disruption of GRP-BB2 signaling had minimal impact on SCN rhythms unless VPAC2 receptors were also blocked.

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