Current biology : CB

How brain cell signals keep the body's internal clock in sync and running

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The Vipr2 gene is essential for maintaining molecular timekeeping and synchronizing SCN neurons.

  • Circadian timekeeping in mammals relies on feedback loops active in peripheral tissues and the suprachiasmatic nuclei (SCN).
  • Spontaneous synchronization of molecular loops in SCN neurons is crucial for their pacemaker function.
  • Vasoactive intestinal polypeptide (VIP) is involved in the activation and synchronization of SCN neurons.
  • Real-time imaging reveals that the VPAC2 receptor, encoded by the Vipr2 gene, is required for synchronizing timekeeping among SCN neurons.
  • Both depolarization and gastrin-releasing peptide (GRP) can temporarily enhance synchrony in Vipr2-deficient SCN neurons.
  • Without VIP signaling, Vipr2-deficient neurons cannot maintain synchrony, indicating the importance of neuropeptidergic signaling in the SCN.

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