Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908)

May 29, 2020Journal of biological rhythms

Lower VIP Levels Affect the Body's Daily Clock in a Specific Mouse Model

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Abstract

Homozygous VIP-Cre mice display a faster reentrainment and shorter free-running period compared to wild-type mice.

  • VIP expression is reduced in both heterozygous and homozygous adult VIP-IRES-Cre mice.
  • Despite altered period and network organization, homozygous VIP-Cre mice maintain intact SCN molecular rhythms.
  • The ability to sustain molecular rhythms in the SCN of VIP-Cre mice is associated with arginine vasopressin signaling, not residual VIP signaling.
  • Loss of VIP expression in VIP-Cre mice can be compensated by other neuropeptide signals.

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