Journal of biological rhythms

Different Functions of VIP Neurons in the Newborn and Adult Body Clock Center

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Ablation of vasoactive intestinal polypeptide (VIP) neurons in adult mice resulted in distinct rhythmic locomotor activity changes.

  • Mice without VIP neurons exhibited a shortened circadian period and more variable daily activity onset.
  • Daily locomotor activity duration decreased in mice lacking VIP neurons.
  • Corticosterone rhythm, a key circadian hormone, was significantly dampened in these mice.
  • Neonatal deletion of SCN VIP neurons led to a dramatic reduction in circadian gene expression in cultured SCN.
  • These findings indicate that SCN VIP neurons are associated with regulating circadian period length and daily glucocorticoid surges.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Funding

Competing interests

Conflict of Interest: The authors declare no competing financial interests.
PubMed

Related papers

Aug '18
Specialized Brain Cells Needed for Normal Light-Based Resetting of the Body’s Internal Clock
top 5% journal
cited by 148 papers
research support, n.i.h., extramural
Mar '05
Vasoactive intestinal polypeptide helps control daily rhythms and coordination in mammal brain clock cells
cited by 687 papers
comparative study
Jan '03
The mouse VPAC2 receptor supports daily cell rhythms and response to a signaling molecule in the brain’s internal clock
top 20% journal
cited by 125 papers
comparative study
Oct '17
Development of Daily Biological Rhythms and Their Coordination in the Brain's Internal Clock
top 5% journal
cited by 91 papers
research support, non-u.s. gov't
Mar '03
Peptide signals play a key role in controlling the body's daily rhythms in the brain's clock center
top 20% journal
cited by 59 papers
research support, non-u.s. gov't
May '20
Lower VIP Levels Affect the Body's Daily Clock in a Specific Mouse Model
cited by 25 papers
research support, n.i.h., extramural
Dec '05
Gastrin-releasing peptide supports daily cell rhythms in the brain's clock without VIP-VPAC2 signaling
top 5% journal
cited by 116 papers
research support, non-u.s. gov't
May '96
No daily rhythm of the blood vessel-regulating peptide VIP in the human body clock center
top 20% journal
cited by 11 papers
journal article
Aug '05
Daily patterns of two brain chemicals in the internal clock of mouse lemurs show age-related changes in time-keeping neurons
top 20% journal
cited by 39 papers
comparative study
Dec '15
Unique Activity Patterns of Vasoactive Intestinal Peptide Neurons in the Brain's Biological Clock
cited by 32 papers
journal article

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #48
A blood test can now estimate your internal clock time using just 60 proteins
2 days ago7 studies
issue #47
Your body clock controls liver fibrosis — and scientists just found the on/off switch
1 week ago7 studies
issue #46
Night shift workers' metabolomes fall out of sync — and glucose pays the price
2 weeks ago7 studies
issue #45
80% of FDA-approved drug targets show clock-dependent activity — timing may be everything
3 weeks ago7 studies
issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
4 weeks ago7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
5 weeks ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
6 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
7 weeks ago7 studies
issue #40
Male mice lived 12% longer when they ate only during an 8-hour window at night
8 weeks ago7 studies
issue #38
Emergency doctors had 67% higher odds of chronic pain when working evening shifts vs. morning shifts
10 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief