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Different Roles for VIP Neurons in the Neonatal and Adult Suprachiasmatic Nucleus
Different Functions of VIP Neurons in the Newborn and Adult Body Clock Center
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Abstract
Ablation of vasoactive intestinal polypeptide (VIP) neurons in adult mice resulted in distinct rhythmic locomotor activity changes.
- Mice without VIP neurons exhibited a shortened circadian period and more variable daily activity onset.
- Daily locomotor activity duration decreased in mice lacking VIP neurons.
- Corticosterone rhythm, a key circadian hormone, was significantly dampened in these mice.
- Neonatal deletion of SCN VIP neurons led to a dramatic reduction in circadian gene expression in cultured SCN.
- These findings indicate that SCN VIP neurons are associated with regulating circadian period length and daily glucocorticoid surges.
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