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Temporal phasing of locomotor activity, heart rate rhythmicity, and core body temperature is disrupted in VIP receptor 2-deficient mice
Timing of movement, heart rate, and body temperature rhythms is disrupted in mice lacking a key brain signaling receptor
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Abstract
VPAC2-deficient mice lose rhythmicity in core body temperature, locomotor activity, and heart rate under constant light or darkness.
- VPAC2 signaling is critical for maintaining functional circadian rhythms in locomotor activity, core body temperature, and heart rate.
- Under constant conditions, VPAC2-deficient mice exhibit a loss of rhythms in all three parameters measured.
- During the light/dark cycle, VPAC2-deficient mice retain 24-hour rhythms but show significant alterations in temperature rhythm, peaking 4-6 hours earlier than wild-type mice.
- The study's findings raise questions regarding the representativeness of wheel-running activity as a measure of circadian behavior in mice with altered circadian phenotypes.
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