European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

MDMA-assisted therapy may improve symptoms and brain function in posttraumatic stress disorder

Updated

Abstract

MDMA-assisted therapy is associated with reductions in PTSD symptom severity (SMD = -1.19).

  • MDMA-assisted therapy may reduce dissociative symptoms (SMD = -0.37).
  • Improvements in functioning are suggested, but the evidence is limited (SMD = -0.83).
  • No clear benefit for depressive symptoms was observed.
  • Most studies showed a high risk of bias in outcome measurement.
  • The overall certainty of the evidence was very low due to limited trials and methodological concerns.

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Full Text

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Funding

Competing interests

Declaration of competing interest SL has received honoraria for service as a consultant or adviser and/or for lectures from Angelini, Apsen, Boehringer Ingelheim, Eisai, Ekademia, Gedeon Richter, Janssen, Johnson & Johnson, Karuna, Kynexis, LB Pharma, LTS Lohmann, Lundbeck, MSD, Medichem, Medscape, Mitsubishi, Neurotorium, NovaNordisk, Otsuka, Recordati, Sandoz, Sanofi-Aventis, Sunovion, Rovi and TEVA. EV has received grants and served as a consultant, advisor or CME speaker for the following entities: AB-Biotics, AbbVie, Adamed, Angelini, BeckleyPsych, Biogen, Biohaven, Boehringer-Ingelheim, Celon Pharma, Compass, Dainippon Sumitomo Pharma, Ethypharm, Ferrer, Gedeon Richter, GH Research, Glaxo-Smith Kline, HMNC, Idorsia, Janssen, Lundbeck, Luye Pharma, Medincell, Merck, Newron, Novartis, Orion Corporation, Organon, Otsuka, Roche, Rovi, Sage, Sanofi-Aventis, Sunovion, Takeda, Teva, and Viatris, outside of the submitted work. SS has received grants from Lundbeck, Sanofi-Aventis, and Servier outside of the submitted work. The other authors report no financial relationships with commercial interests.
PubMed

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