MDS-UPDRS to assess non-motor symptoms after STN DBS for Parkinson's disease

Jul 3, 2015The International journal of neuroscience

Using MDS-UPDRS to measure non-movement symptoms after deep brain stimulation in Parkinson’s disease

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Abstract

One year following bilateral subthalamic nucleus deep brain stimulation, significant improvements were observed in sleep and urinary problems as measured by the MDS-UPDRS.

No significant changes were found in individual non-motor symptoms or the total mentation score of the original UPDRS after one year.
The MDS-UPDRS indicated a trend towards improvement in anxiety, constipation, daytime sleepiness, fatigue, and pain.
The findings suggest that the non-motor sections of the MDS-UPDRS could effectively measure changes in non-motor symptoms in Parkinson's disease patients post-surgery.

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OBJECTIVE: To determine if the non-motor sections of the Movement Disorder Society's (MDS) version of the Unified Parkinson's Disease Rating Scale (UPDRS) could supplement the original UPDRS as a patient completed assessment of changes in non-motor symptoms in Parkinson's disease (PD) patients after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS).

METHODS: Thirty PD patients who underwent bilateral STN DBS were assessed using the total UPDRS and the non-motor sections of the MDS-UPDRS prior to surgery and one year following surgery. This study focuses on non-motor symptoms as assessed by Part I of the UPDRS and Part 1A and 1B of the MDS-UPDRS.

RESULTS: One year following surgery, no individual non-motor symptoms or the total mentation score of the UPDRS were significantly changed. In comparison, the MDS-UPDRS showed significant improvements in sleep and urinary problems and a trend towards improvement in anxiety, constipation, daytime sleepiness, fatigue and pain.

CONCLUSIONS: This study provides evidence that the MDS-UPDRS non-motor sections, when completed by the patients, can supplement the original version of the UPDRS as an effective method of measuring changes in non-motor symptoms after DBS. It also reinforces the benefits of bilateral STN DBS on non-motor symptoms of PD.

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MDS-UPDRS to assess non-motor symptoms after STN DBS for Parkinson's disease

Abstract

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