Medical and Mental Health Consultations to Reduce Risks for Patients Considering Legal Psilocybin Treatment: A Model and Two Case Examples

Two case studies highlight the complexities of patient experiences with psilocybin services.

• A middle-aged man with alcohol use disorder showed early improvement and achieved abstinence through a nonlinear recovery process after two psilocybin sessions.
• He experienced a distressing high-dose unsupervised psilocybin event, which led to the need for PEACE-supported integration care.
• An older woman with major depressive disorder experienced a worsening of her condition three months after completing two supervised psilocybin experiences.
• Longitudinal follow-up is important, as initial improvements may not indicate sustained recovery.
• The PEACE model may facilitate informed decision-making, risk reduction, and continuity of care in psilocybin-related treatment.

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