Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus.

Oct 29, 1998Diabetes

How melanin-concentrating hormone, neuropeptide Y, and appetite-reducing signals interact in the rat's hunger control area

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Intracerebroventricular administration of GLP-1 completely prevents the appetite-stimulating effects of both MCH and NPY.

MCH and NPY are identified as potent appetite stimulants.
Alpha-MSH, neurotensin, and GLP-1(7-36) amide are associated with appetite suppression.
GLP-1 administration blocks the effects of both MCH and NPY on food intake.
Alpha-MSH inhibits the appetite-stimulating effect of MCH but not NPY.
Neurotensin similarly prevents the orexigenic effect of MCH but does not affect NPY.

AI simplified

A growing body of evidence indicates that a number of peptides expressed in the mammalian hypothalamus are involved in the regulation of food intake and energy balance. Among these, melanin-concentrating hormone (MCH) and neuropeptide Y (NPY) are potent appetite stimulants, whereas alpha-melanocyte-stimulating hormone (alpha-MSH), neurotensin, and glucagon-like peptide (GLP)-1(7-36) amide have appetite-suppressing properties. However, the functional interactions between pathways involving these neuropeptides remain incompletely understood. In the current study, we describe the functional interactions between orexigenic (appetite-stimulating: MCH and NPY) and anorectic (appetite-suppressing: alpha-MSH, neurotensin, and GLP-1) peptides after intracerebroventricular (i.c.v.) administration in the rat. The i.c.v. administration of GLP-1 completely prevents the orexigenic effects of both MCH and NPY. However, i.c.v. administration of alpha-MSH prevents only the orexigenic effect of MCH, as we have previously shown, but does not prevent the effect of NPY on food intake. Similarly, i.c.v. administration of neurotensin prevents only the orexigenic effect of MCH, but does not prevent the appetite-stimulating effect of NPY. Thus, our study suggests that the functional interactions between these neuropeptides are specific, although the underlying mechanisms are as yet unexplored.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text ↗

Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus.

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief