Melanocortin-4 receptor polymorphism rs17782313: Association with obesity and eating in the absence of hunger in Chilean children

The frequency of the C-allele of MC4R rs17782313 was higher in the obese group than in the control group.

• The odds ratio for the association between the C-allele and obesity was 1.4, but this finding did not reach statistical significance.
• Children with the CC genotype had higher scores for 'enjoyment of food' and lower scores for 'satiety responsiveness' compared to those with the TT genotype.
• In the Eating in the Absence of Hunger test, non-obese carriers of the C-allele showed increased sweet snack consumption after a preload meal, although this result was not statistically significant.

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