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Abstract
Melatonin administration enhanced and stabilized the circadian rest-activity rhythm in one of two Alzheimer's patients.
- Dementia is linked to disturbances in circadian rhythms, affecting body temperature, hormones, sleep, and activity patterns.
- A decline in melatonin rhythm amplitude is associated with aging.
- One Alzheimer's patient experienced reduced daytime sleepiness and improved mood following melatonin treatment.
- The second patient, with less cognitive impairment, did not show significant changes after melatonin ingestion.
- Both patients had a delay of about one hour in their rest-activity rhythm's peak time.
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