Effects of Melatonin in Two Individuals with Alzheimer's Disease

Melatonin administration enhanced and stabilized the circadian rest-activity rhythm in one of two Alzheimer's patients.

• Dementia is linked to disturbances in circadian rhythms, affecting body temperature, hormones, sleep, and activity patterns.
• A decline in melatonin rhythm amplitude is associated with aging.
• One Alzheimer's patient experienced reduced daytime sleepiness and improved mood following melatonin treatment.
• The second patient, with less cognitive impairment, did not show significant changes after melatonin ingestion.
• Both patients had a delay of about one hour in their rest-activity rhythm's peak time.

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