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Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats
Melatonin treatment boosts antioxidants and lowers fat levels in rat brain and liver
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Abstract
Daily administration of melatonin for 45 days at doses of 0.5 and 1.0 mg/kg significantly decreased lipid peroxidation and levels of various lipids in rats.
- Both doses of melatonin significantly reduced cholesterol, phospholipids, triglycerides, and free fatty acids in the brain and liver.
- Melatonin treatment increased the activity of antioxidant enzymes in both the brain and liver.
- Levels of glutathione were elevated following melatonin treatment.
- These findings support the idea that melatonin may reduce oxidative stress and could function as an antihyperlipidemic agent.
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