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Melatonin improves the homeostasis of mice gut microbiota rhythm caused by sleep restriction
Melatonin helps balance daily gut bacteria rhythms disrupted by sleep loss in mice
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Abstract
Chronic sleep loss disrupts the pattern of colonic microbial communities and reduces the proportion of gut microbiota with a circadian rhythm.
- Sleep restriction alters the normal circadian rhythm of intestinal microbiota.
- Reduction in gut microbiota with a circadian rhythm is observed following chronic sleep loss.
- Exogenous melatonin supplementation restores the proportion of gut microbiota with a circadian rhythm.
- Melatonin also increases the activity of metabolic pathways that follow a circadian rhythm.
- Certain families of gut bacteria, specifically Muribaculaceae and Lachnospiraceae, are sensitive to sleep restriction and can be rescued by melatonin.
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