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Melatonin induces Nrf2‐HO‐1 reprogramming and corrections in hepatic core clock oscillations in Non‐alcoholic fatty liver disease
Melatonin may reset liver’s daily rhythm and protective responses in fatty liver disease
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Abstract
Melatonin treatment (100 µM) improved the oscillatory patterns of clock genes in liver cells under circadian desynchrony.
- High-fat high fructose diet and jet lag are linked to disruptions in liver circadian clock genes and lipid metabolism.
- Melatonin administration corrected oscillations in specific clock genes (Clock and Bmal1) but had no effect on others (Cry, Nrf2, and HO-1).
- In C57BL/6J mice, melatonin treatment improved lipid regulatory gene profiles and liver function indicators (AST and ALT).
- Moderate improvements were observed in the oscillations of other clock genes (Per1, Per2, and Cry2) following melatonin treatment.
- Melatonin also influenced oscillations of antioxidant genes, contributing to the overall improvement in non-alcoholic fatty liver disease.
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