Tea polyphenols may help the body clock improve cell energy balance and protect liver cells

Tea polyphenols (TP) may enhance the circadian clock's role in protecting against oxidative stress.

• TP reduce fluctuations in the transcription and protein expression of circadian clock genes triggered by oxidative stress.
• TP decrease the secretion of reactive oxygen species (ROS) and help restore mitochondrial function.
• The protective effects of TP are associated with the Bmal1 protein, which is involved in regulating circadian rhythms.
• TP treatment promotes the movement of the Nrf2 protein into the nucleus, influencing the expression of antioxidant enzymes.
• Knockdown of Bmal1 disrupts the Nrf2/ARE/HO-1 pathway, indicating its significance in the antioxidant response.

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