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Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes
Tea polyphenols may help the body clock improve cell energy balance and protect liver cells
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Abstract
Tea polyphenols (TP) may enhance the circadian clock's role in protecting against oxidative stress.
- TP reduce fluctuations in the transcription and protein expression of circadian clock genes triggered by oxidative stress.
- TP decrease the secretion of reactive oxygen species (ROS) and help restore mitochondrial function.
- The protective effects of TP are associated with the Bmal1 protein, which is involved in regulating circadian rhythms.
- TP treatment promotes the movement of the Nrf2 protein into the nucleus, influencing the expression of antioxidant enzymes.
- Knockdown of Bmal1 disrupts the Nrf2/ARE/HO-1 pathway, indicating its significance in the antioxidant response.
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