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Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes
Nobiletin helps prevent insulin resistance and fat metabolism problems by resetting the body clock in liver cells
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Abstract
Nobiletin (NOB) may partially reverse disruptions in circadian clock gene oscillations in primary liver cells under metabolic disorder conditions.
- NOB effectively amplifies glucose uptake through stimulation of the IRS-1/AKT signaling pathway.
- NOB reduces lipogenesis induced by palmitate in liver cells by modulating specific signaling pathways and enzymes.
- NOB decreases excessive reactive oxygen species (ROS) production and restores mitochondrial membrane potential.
- NOB's effects on metabolic balance and mitochondrial function are linked to the core clock gene Bmal1.
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