Journal of agricultural and food chemistry

Capsaicin may improve oxidative balance and sugar metabolism problems in insulin resistance through body clock-related processes

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Abstract

Capsaicin may improve glucose metabolism disorders and redox imbalance in insulin-resistant HepG2 cells.

  • Circadian rhythms are linked to metabolic balance.
  • Bioactive components can influence clock gene expression.
  • Capsaicin has shown anti-obesity and anti-insulin resistance effects.
  • Glucosamine treatment induced insulin resistance in HepG2 cells.
  • Capsaicin cotreatment improved glucose uptake and reduced reactive oxygen species.
  • Circadian misalignment was alleviated by capsaicin treatment.

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