Full text is available at the source.
Melatonin pathway: breaking the ‘high-at-night’ rule in trout retina
Melatonin signaling that breaks the usual nighttime pattern in trout eye
AI simplified
Abstract
Light increases the activity and abundance of retinal AANAT1 in trout while decreasing pineal AANAT2 levels.
- Pineal melatonin synthesis typically increases at night across vertebrates due to heightened AANAT activity.
- In trout, retinal melatonin synthesis patterns differ, with AANAT1 activity peaking during the day instead of the night.
- Light exposure raises the levels and activity of retinal AANAT1, while darkness reduces it, contrasting with pineal AANAT2 activity.
- Retinal AANAT protein and activity demonstrate rhythmic changes that are out of phase with retinal AANAT1 mRNA levels.
- These findings suggest that retinal melatonin behavior in trout may represent an adaptation for photoadaptation or detoxification.
AI simplified